Fields of Interest

Dr. Tove Agner

• Irritant contact dermatitis
  
• Combined effect of irritants and allergens
  
• Bioengineering methods
  
• Occupational hand eczema – risk factors and prognosis
  
• Hand eczema – twin studies – incidence and prognosis
  
• Information and compliance in relation to allergic contact dermatitis
  
• Atopic dermatitis – birth cohort study
  

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Prof. Klaus E. Andersen

• Perfume allergy – allergy to natural products (Compositae extracts)
  
• Compositae allergy
  
• Birth cohort study. Follow up of newborns with respect to development of atopic diseases, eczema and type I & IV allergy (Co 4).
  
• “In vivo” models to evaluate anti-irritant effect of topicals
  
• Incidence of acute skin drug reactions in a major hospital
  
• Allergen Bank
  

1. Lomholt H, Rastogi SC, Andersen KE.
   Allergic contact dermatitis from sodium dihydroxycetyl phosphate, a new cosmetic allergen?
   Contact Dermatitis 2001; 45(3):143-145.
   Abstract


2. Paulsen E, Andersen KE, Hausen BM.
   An 8-year experience with routine SL mix patch testing supplemented with Compositae mix in Denmark.
   Contact Dermatitis 2001; 45(1):29-35.
   Abstract


3. Agner T, Andersen KE, Bjorkner B, Bruze M, Frosch PJ, Gruvberger B et al.
   Standardization of the TRUE Test imidazolidinyl urea and diazolidinyl urea patches.
   Contact Dermatitis 2001; 45(1):21-25.
   Abstract


4. Mortz CG, Lauritsen JM, Bindslev-Jensen C, Andersen KE.
   Prevalence of atopic dermatitis, asthma, allergic rhinitis, and hand and contact dermatitis in adolescents. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis.
   Br J Dermatol 2001; 144(3):523-532.
   Abstract


5. Frankild S, Lepoittevin JP, Kreilgaard B, Andersen KE.
   Tixocortol pivalate contact allergy in the GPMT: frequency and cross-reactivity.
   Contact Dermatitis 2001; 44(1):18-22.
   Abstract

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Dr. Francisco M. Brandão

• Cosmetic dermatitis (preservatives)
  
• Latex C.U.
  
• Prevalence in surgical staff of the Hospital (continuing)
  
• Textile dye mix: collaboration in the development and follow-up study
  
• Clinical contact dermatitis
  
• Occupational dermatoses in governmental occupational department
  

1. Brandao FM.
   Palmar contact dermatitis due to (meth)acrylates.
   Contact Dermatitis 2001; 44(3):186-187.
   Abstract
   
2. Isaksson M, Brandao FM, Bruze M, Goossens A.
   Recommendation to include budesonide and tixocortol pivalate in the European standard series. ESCD and EECDRG. European Society of Contact Dermatitis.
   Contact Dermatitis 2000; 43(1):41-42.
   Abstract
   
3. Isaksson M, Andersen KE, Brandao FM, Bruynzeel DP, Bruze M, Diepgen T et al.
   Patch testing with budesonide in serial dilutions. A multicentre study of the EECDRG.
   Contact Dermatitis 2000; 42(6):352-354.
   Abstract
   
4. Isaksson M, Andersen KE, Brandao FM, Bruynzeel DP, Bruze M, Camarasa JG et al.
   Patch testing with corticosteroid mixes in Europe. A multicentre study of the EECDRG.
   Contact Dermatitis 2000; 42(1):27-35.
   Abstract
   
5. Paulsen E, Andersen KE, Brandao FM, Bruynzeel DP, Ducombs G, Frosch PJ et al.
   Routine patch testing with the sesquiterpene lactone mix in Europe: a 2-year experience. A multicentre study of the EECDRG.
   Contact Dermatitis 1999; 40(2):72-76.
   Abstract
   
6. Bartolo E, Anes I, Capitao-Mor M, Brandao FM.
   Idiopathic plantar hidradenitis.
   J Eur Acad Dermatol Venereol 1998; 10(3):257-261.
   Abstract

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Prof. Derk P. Bruynzeel

• NECOD: Occupational Contact Dermatoses project
  
• Patch tests methods
  
• Contact allergy and irritation: mechanisms (see R. Scheper)
  
• Contact dermatoses in agriculture
  
• Metal industry
  
• Dermatology life quality index for hand eczema
  

1. Vermeer MH, Bruynzeel DP.
   Mouse fingers, a new computer-related skin disorder.
   J Am Acad Dermatol 2001; 45(3):477.
   Abstract
   
2. Vermeulen R, Kromhout H, Bruynzeel DP, de Boer EM, Brunekreef B.
   Dermal exposure, handwashing, and hand dermatitis in the rubber manufacturing industry.
   Epidemiology 2001; 12(3):350-354.
   Abstract
   
3. Alanko K, Tuomi T, Vanhanen M, Pajari-Backas M, Kanerva L, Havu K et al.
   Occupational IgE-mediated allergy to Tribolium confusum (confused flour beetle).
   Allergy 2000; 55(9):879-882.
   Abstract
   
4. Kunkeler L, Bikkers SC, Bezemer PD, Bruynzeel DP.
   (Un)usual effects of patch testing?
   Br J Dermatol 2000; 143(3):582-586.
   Abstract
   
5. Jonker MJ, Bruynzeel DP.
   The outcome of an additional patch-test reading on days 6 or 7.
   Contact Dermatitis 2000; 42(6):330-335.
   Abstract
   
6. Vermeulen R, Kromhout H, Bruynzeel DP, de Boer EM.
   Ascertainment of hand dermatitis using a symptom-based questionnaire; applicability in an industrial population.
   Contact Dermatitis 2000; 42(4):202-206.
   Abstract
   

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Prof. Magnus Bruze

• Corticosteroids (Co 1)
  
• Epoxy resins (Co 2)
  
• Gold *
  
• Nickel (Co 3)
  
• Perfume **
  
• Phenol-formaldehyde resins (Co 4)
  
• Preservatives (Co 5)
  
• Isocyanates ***
  

1. Isaksson M, Bruze M, Lepoittevin JP, Goossens A.
   Patch testing with serial dilutions of budesonide, its R and S diastereomers, and potentially cross-reacting substances.
   Am J Contact Dermat 2001; 12(3):170-176.
   Abstract
   
2. Isaksson M, Bruze M.
   Repetitive usage testing with budesonide in experimental nickel--allergic contact dermatitis in individuals hypersensitive to budesonide.
   Br J Dermatol 2001; 145(1):38-44.
   Abstract
   
3. Nilsson AM, Gafvert E, Salvador L, Luthman K, Bruze M, Gruvberger B et al.
   Mechanism of the antigen formation of carvone and related alpha, beta-unsaturated ketones.
   Contact Dermatitis 2001; 44(6):347-356.
   Abstract
   
4. Hindsen M, Bruze M, Christensen OB.
   Flare-up reactions after oral challenge with nickel in relation to challenge dose and intensity and time of previous patch test reactions.
   J Am Acad Dermatol 2001; 44(4):616-623.
   Abstract
   
5. Ponten A, Bruze M.
   Contact allergy to epoxy resin based on diglycidyl ether of bisphenol F.
   Contact Dermatitis 2001; 44(2):98-99.
   Abstract
   

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Prof. Thomas L. Diepgen

• ATOPIC DERMATITIS and atopy:
  natural history of AD; prognostic factors; subgroups; autoallergy; epidemiology; evaluation of eczema schools for AD (funded by German Health Ministry)
  
• OCCUPATIONAL CONTACT DERMATITIS
  register study of OCD in North Bavaria and Saarland; prospective AUDI cohort study; secondary prevention program in health care workers, rehabilitation of OCD; prospective cohort study in hairdressers and nurses; costs of OCD
  
• REGULATION (occupational skin diseases, allergens, irritants)
  
• SUN-ALLERGY (EU project)
  
• EVIDENCE BASED DERMATOLOGY (Cochrane Skin Group, antihistamines in AD)
  
• DERMATOLOGY & INTERNET
  Dermatology Online Atlas, CD-ROM, e-Health: MedCertain (EU-project), Internet-based health education & prevention for AD, skin cancer
  
• OTHERS
  Efficacy of barrier creams (using bio-engineering methods)
  Skin cancer prevention: screening programmes in companies
  Prevalence of skin diseases in Europe (cooperation with EDEN, EDF)
  

1. Diepgen TL, Coenraads PJ (1999)
   The epidemiology of occupational contact dermatitis.
   Int Arch Occup Environ Health 72: 496-506
   Abstract
   
2. Diepgen TL, Coenraads PJ (2000)
   The impact of sensitivity, specificity and positive predictive value of patch testing: The more you test, the more you get?
   Contact Dermatitis 42:315?7
   Abstract
   
3. Mahler V, Diepgen TL, Kuss O, Leakakos T, Truscott W, Schuler G, Kraft D, Valenta R (2000)
   Mutual boosting effects of sensitization with timothy grass pollen and latex glove extract on IgE antibody responses in a mouse model.
   J Invest Dermatol. 114(5):1039?43
   Abstract
   
4. Schnetz E, Diepgen TL, Elsner P, Frosch PJ, Klotz AJ, Kresken J, Kuss O, Merk H, Schwanitz HJ, Wigger?Alberti W, Fartasch M (2000)
   Multicentre study for the development of an in vivo model to evaluate the influence of topical formulations on irritation.
   Contact Dermatitis 42: 336?43
   Abstract
   
5. Funke U, Fartasch M, Diepgen TL (2001)
   Incidence of work related hand eczema in apprenticeship - first results of a prospective cohort study in the car industry.
   Contact Dermatitis 44:166-172
   Abstract
   
6. Dickel H, Kuss O, Blesius CR, Schmidt A, Diepgen TL (2001)
   Report from the register of occupational skin diseases in Nothern Bavaria (BKH-N).
   Contact Dermatitis 44: 258-9
   Abstract
   
7. Dickel H, Kuss O, Blesius CR, Schmidt A, Diepgen TL (2001)
   Occupational skin diseases in Nothern Bavaria between 1990 and 1999: a population based study.
   Br J Dermatol 145(3): 453-462
   Abstract
   
8. Diepgen TL (2001)
   Atopic Dermatitis - The Role of Social Factors.
   J Am Acad Dermatol. 45: S44-8
   Abstract
   
9. Eysenbach G, Diepgen TL (2001)
   The role of e-health and consumer health informatics for evidence-based patient choice.
   Clinics in Dermatology 19: 11-17
   Abstract
   

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Jeanne Duus Johansen

• Perfume allergy
  
• Contact allergy to hair dyes
  
• Contact allergy to preservatives
  
• Contact allergy to chromium
  
• Combination effects: irritants/allergens
  
• Airway symptoms related to perfume exposure
  
• Risk assessment model for elicitation of contact allergy
  
• Threshold of reaction to systemic nickel exposure
  
• Disease patterns related to contact allergy
  
• Surveillance systems for contact allergy
  
• Occupational contact dermatitis
  
• Eczema prognosis
  

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Prof. Peter J. Frosch

• Frequency of new allergens (patch test series)
  
• Contact allergy to chromate – quantitative aspects
  
• Fragrances (EU study) - new fragrance mix
  
• SLS irritancy and its use in patch testing with allergens
  

1. Loffler H, Pirker C, Aramaki J, Frosch PJ, Happle R, Effendy I.
   Evaluation of skin susceptibility to irritancy by routine patch testing with sodium lauryl sulfate.
   Eur J Dermatol 2001; 11(5):416-419.
   Abstract
   
2. Brinkmeier T, Frosch PJ.
   Pyodermatitis-pyostomatitis vegetans: a clinical course of two decades with response to cyclosporine and low-dose prednisolone.
   Acta Derm Venereol 2001; 81(2):134-136.
   Abstract
   
3. Watermann DF, Kiesewetter F, Frosch PJ.
   [Skin manifestations of Erdheim-Chester disease. Case report and review of the literature.]
   Hautarzt 2001; 52(6):510-517.
   Abstract
   
4. Johansen JD, Frosch PJ, Rastogi SC, Menne T.
   Testing with fine fragrances in eczema patients: results and test methods.
   Contact Dermatitis 2001; 44(5):304-307.
   Abstract
   
5. Magerl A, Heiss R, Frosch PJ.
   Allergic contact dermatitis from zinc ricinoleate in a deodorant and glyceryl ricinoleate in a lipstick.
   Contact Dermatitis 2001; 44(2):119-121.
   Abstract
   

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Dr. Margarida Goncalo

• Patch testing in drug eruptions.
  
• Photosensitivity. Skin testing, phototesting and photopatch testing.
  
• Standardization in photopatch testing (European task Force for the Standardization of photopatch testing)
  
• Plant dermatitis and allergen protection by gloves
  
• Clinical and occupational dermatitis
  
• In vitro activation of dendritic cells by skin sensitizers
  
• Chronic urticaria
  
• Pharmacovigilance
  

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Prof. An Goossens

• Different aspects of contact dermatitis to corticosteroids, such as cross sensitivity
  
• Contact dermatitis to cosmetics
  
• Occupational contact dermatitis (in cooperation with M. Bruze)
  
• Computer applications for practising dermatologists (Co 2)
  
  CODEX (pharmaceutical products)
  COSME (cosmetic products)
  INFAL (information on allergens and sensitization sources)
  CDREF (in cooperation with L. Conde Salazar, contact dermatitis literature references)
  EXPCA (expert program on P. C.)
  CFLDR (patient information)
  CDESK (combination of list functions of CODEX, COSME, CFLDR)
  PATCH (hierarchical search for allergens)
  

1. Isaksson M, Brandao FM, Bruze M, Goossens A.
   Recommendation to include budesonide and tixocortol pivalate in the European standard series. ESCD and EECDRG. European Society of Contact Dermatitis.
   Contact Dermatitis 2000; 43(1):41-42.
   Abstract
   
2. De Maeseneer M, Shahabpour M, Van Roy F, Goossens A, De Ridder F, Clarijs J et al.
   Mr imaging of the medial collateral ligament bursa: findings in patients and anatomic data derived from cadavers.
   AJR Am J Roentgenol 2001; 177(4):911-917.
   Abstract
   
3. Goossens A, Bedert R, Zimerson E.
   Allergic contact dermatitis caused by nickel and cobalt in green plastic shoes.
   Contact Dermatitis 2001; 45(3):172.
   Abstract
   
4. Huygens S, Barbaud A, Goossens A.
   Frequency and relevance of positive patch tests to cyclohexylthiophthalimide, a new rubber allergen.
   Eur J Dermatol 2001; 11(5):443-445.
   Abstract
   
5. De Paepe K, Hachem JP, Vanpee E, Goossens A, Germaux MA, Lachapelle JM et al.
   Beneficial effects of a skin tolerance-tested moisturizing cream on the barrier function in experimentally-elicited irritant and allergic contact dermatitis.
   Contact Dermatitis 2001; 44(6):337-343.
   Abstract
   

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Dr. Arto Lahti

• Contact urticaria especially non-immunologic type
  
• Testing methods for the immediate type irritancy caused by chemicals
  
• Protein contact dermatitis
  

1. Kanerva L, Rantanen T, Aalto-Korte K, Estlander T, Hannuksela M, Harvima RJ et al.
   A multicenter study of patch test reactions with dental screening series.
   Am J Contact Dermat 2001; 12(2):83-87.
   Abstract
   
2. Korhonen R, Kankaanranta H, Lahti A, Lahde M, Knowles RG, Moilanen E.
   Bi-directional effects of the elevation of intracellular calcium on the expression of inducible nitric oxide synthase in J774 macrophages exposed to low and to high concentrations of endotoxin.
   Biochem J 2001; 354(Pt 2):351-358.
   Abstract
   
3. Isaksson M, Andersen KE, Brandao FM, Bruynzeel DP, Bruze M, Diepgen T et al.
   Patch testing with budesonide in serial dilutions. A multicentre study of the EECDRG.
   Contact Dermatitis 2000; 42(6):352-354.
   Abstract
   

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Christophe le Coz

• Textile dermatitis
  
• Occupational contct dermatitis
  
• Ketoprofen (photo)contact dermatitis and consequences
  
• Development of patch testing improvement
  

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Prof. Jean-Pierre Lepoittevin

• Molecular toxicology
  
  • Xenobiotics
    
  • Interactions with proteins (e.g. aldehydes, kathon)
    
  • Formation of radicals (e.g. terpene-hydroperoxides)
    
  • Interest in alkylating agents
    
  • Interaction with DNA (chronic actinic dermatitis)
    
  • Development of SAR's and QSAR's
  
  
• Perfume allergy (EU project)
  
• Identification of oak-moss sensitisers
  

1. Isaksson M, Bruze M, Lepoittevin JP, Goossens A.
   Patch testing with serial dilutions of budesonide, its R and S diastereomers, and potentially cross-reacting substances.
   Am J Contact Dermat 2001; 12(3):170-176.
   Abstract
   
2. Le Coz CJ, Lepoittevin JP.
   Clothing dermatitis from Naphthol AS.
   Contact Dermatitis 2001; 44(6):366-367.
   Abstract
   
3. Le Coz CJ, Lepoittevin JP.
   Occupational erythema-multiforme-like dermatitis from sensitization to costus resinoid, followed by flare-up and systemic contact dermatitis from beta-cyclocostunolide in a chemistry student.
   Contact Dermatitis 2001; 44(5):310-311.
   Abstract
   
4. Lepoittevin JP, Meschkat E, Huygens S, Goosens A.
   Presence of resin acids in "Oakmoss" patch test material: a source of misdiagnosis?
   J Invest Dermatol 2000; 115(1):129-130.
   Abstract
   
5. Isaksson M, Bruze M, Goossens A, Lepoittevin JP.
   Patch-testing with serial dilutions of tixocortol pivalate and potential cross-reactive substances.
   Acta Derm Venereol 2000; 80(1):33-38.
   Abstract
   

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Prof. Howard I. Maibach

• Effect of moisturizers on the skin
  
• Patterns of hand eczema (visual and instrumental examinations)
  
• Decontamination of chemicals from the skin
  
• Predictability - QSAR
  
• Percutaneous penetration
  
• Irritant dermatitis syndrome
  

1. Levin CY, Maibach HI.
   Do cool water or physiologic saline compresses enhance resolution of experimentally-induced irritant contact dermatitis?
   Contact Dermatitis 2001; 45(3):146-150.
   Abstract
   
2. Mallon J, Chu MT, Maibach HI.
   Occupational allergic contact dermatitis from methyl chloroform (1,1,1-trichloroethane)?
   Contact Dermatitis 2001; 45(2):107.
   Abstract
   
3. Jerschow E, Hostynek JJ, Maibach HI.
   Allergic contact dermatitis elicitation thresholds of potent allergens in humans.
   Food Chem Toxicol 2001; 39(11):1095-1108.
   Abstract
   
4. Singh J, Gross M, Sage B, Davis HT, Maibach HI.
   Regional variations in skin barrier function and cutaneous irritation due to iontophoresis in human subjects.
   Food Chem Toxicol 2001; 39(11):1079-1086.
   Abstract
   
5. Dannaker CJ, Maibach HI, Austin E.
   Allergic contact dermatitis to proparacaine with subsequent cross-sensitization to tetracaine from ophthalmic preparations.
   Am J Contact Dermat 2001; 12(3):177-179.
   Abstract
   

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Thomas Rustemeyer

• Identification of potential contact allergens: development of dendritic cell-(line) based models, ex vivo en in vitro skin models
  
• Allergic contact dermatitis: identification of allergen-specific effector T cell types and regulatory (cell-based) mechanisms, cross-reactivity studies (using the retest model for in in vivo and (clonal) T cells for in vitro studies)
  
• Irritant contact dermatitis: identification of genetic risk factors for the development of irritant contact dermatitis
  
• In vivo and in vitro studies on the potential role of metal contact allergy in patients with intra-oral complaints.
  
• Development of improved diagnostic and therapeutic approaches in patients with allergy to insulin and/or insulin-additives

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Prof. Rik J. Scheper

• Multidrug resistance: mechanisms protecting cells against exogenous toxic substances
  
• Tumor immunology: development of dendritic cell-based vaccines, aiming at T cell-mediated immunity; (reversal of) immunological tolerance
  
• Contact allergy: same mechanistic approaches as previous project: e.g.
  - effect of allergens on Langerhans' cells migration
  - cross-reactivity studies (in vivo Guinea pig model, including retest model; in-vitro T-cell clonal approach)
  - cytokine studies, related to immunological tolerance, Th1, Th2, ... (Co 1, in collaboration with Peter Frosch)
  - retest model studies
  

1. Hensbergen PJ, van Der Raaij-Helmer EM, Dijkman R, Der Schors RC, Werner-Felmayer G, Boorsma DM et al.
   Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity.
   Eur J Biochem 2001; 268(18):4992-4999.
   Abstract
   
2. van der Vliet HJ, von Blomberg BM, Nishi N, Reijm M, Voskuyl AE, van Bodegraven AA et al.
   Circulating V(alpha24+) Vbeta11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage.
   Clin Immunol 2001; 100(2):144-148.
   Abstract
   
3. Siva AC, Raval-Fernandes S, Stephen AG, LaFemina MJ, Scheper RJ, Kickhoefer VA et al.
   Up-regulation of vaults may be necessary but not sufficient for multidrug resistance.
   Int J Cancer 2001; 92(2):195-202.
   Abstract
   
4. de Jong MC, Slootstra JW, Scheffer GL, Schroeijers AB, Puijk WC, Dinkelberg R et al.
   Peptide transport by the multidrug resistance protein MRP1.
   Cancer Res 2001; 61(6):2552-2557.
   Abstract
   
5. Schellens JH, Maliepaard M, Scheper RJ, Scheffer GL, Jonker JW, Smit JW et al.
   Transport of topoisomerase I inhibitors by the breast cancer resistance protein. Potential clinical implications.
   Ann N Y Acad Sci 2000; 922:188-194.
   Abstract
   

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Dr. Ian R. White

• Regulatory aspects and consumer protection
  
• Type I reactions
  
• Preservative allergy
  
• Fragrances – allergens and allergy control
  
• Contact urticaria
  
• Clinical contact dermatitis
  
• Photopatch testing
  
• Hair dye allergen control
  

1. Fletcher CL, White IR.
   Type I hypersensitivity to latex and fungal alpha-amylase in a laboratory worker.
   Contact Dermatitis 2001; 45(3):165.
   Abstract
   
2. Basketter DA, Wright ZM, Warbrick EV, Dearman RJ, Kimber I, Ryan CA et al.
   Human potency predictions for aldehydes using the local lymph node assay.
   Contact Dermatitis 2001; 45(2):89-94.
   Abstract
   
3. McFadden JP, Ross JS, White IR, Basketter DA.
   Clinical allergy to cocamidopropyl betaine: reactivity to cocamidopropylamine and lack of reactivity to 3-dimethylaminopropylamine.
   Contact Dermatitis 2001; 45(2):72-74.
   Abstract
   
4. Wakelin SH, Smith H, White IR, Rycroft RJ, McFadden JP.
   A retrospective analysis of contact allergy to lanolin.
   Br J Dermatol 2001; 145(1):28-31.
   Abstract
   
5. Banerjee P, White IR.
   Allergic contact dermatitis at the application site of an electrosurgical earthing plate occurring in a windscreen repairer.
   Contact Dermatitis 2001; 44(2):97.
   Abstract
   

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